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GPSM2/PRKCI/PARD6B/LLGL2 complex
Function:
1) may ensure correct organization orientation of bipolar spindles for normal cell division
2) role in the initial phase of establishment of epithelial cell polarity
Structure:
- subunits: GPSM2, PRKCI, PARD6B, LLGL2
Compartment:
- cytoplasm
- localized in perinuclear structure & faintly at the cell-cell contacts sites during interphase
- localized at the cell periphery during metaphase
- cortical localization in mitotic cells
- found in the lateral region of polarized epithelial cells
Expression:
3) complex is enhanced during mitosis
General
molecular complex
Properties
SUBUNITS: G-protein-signaling modulator 2
COMPARTMENT: cytoplasm
MOTIF: tetratricopeptide repeat {17-50}
tetratricopeptide repeat {55-88}
tetratricopeptide repeat {95-128}
MOTIF: Ser phosphorylation site {S125}
tetratricopeptide repeat {135-177}
tetratricopeptide repeat {195-228}
tetratricopeptide repeat {235-268}
tetratricopeptide repeat {275-308}
tetratricopeptide repeat {315-348}
MOTIF: Ser phosphorylation site {S345}
Ser phosphorylation site {S401}
GoLoco domain {482-504}
MOTIF: Ser phosphorylation site {S494}
GoLoco domain {537-559}
GoLoco domain {587-609}
MOTIF: Ser phosphorylation site {S600}
GoLoco domain {621-643}
protein kinase C-iota
COMPARTMENT: cytoplasm
cell nucleus
STATE: active state
MOTIF: Regulatory {1-244}
MOTIF: RAB2 interaction {1-19}
OPR {16-99}
PARD6A interaction {63-82}
Zinc finger
NAME: Zinc finger
SITE: 131-181
EFFECTOR-BOUND: Zn+2
kinase domain
SITE: 245-513
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 251-259
Tyr phosphorylation site {Y256}
Tyr phosphorylation site {Y271}
ATP-binding site
NAME: ATP-binding site
SITE: 274-274
Tyr phosphorylation site {Y325}
aspartate residue {D369}
Thr phosphorylation site {T403}
AGC-kinase C-terminal {514-585}
MOTIF: Thr phosphorylation site {T555}
partitioning defective 6 homolog beta
COMPARTMENT: cytoplasm
MOTIF: OPR {16-96}
binding site
SITE: 126-253
FOR-BINDING-OF: partitioning-defective 3 homolog
Cdc42
MOTIF: CRIB domain {133-150}
PDZ domain
NAME: PDZ domain
SITE: 157-250
lethal(2) giant larvae protein homolog 2
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: WD repeat {30-69}
WD repeat {71-110}
WD repeat {186-226}
WD repeat {228-267}
WD repeat {410-460}
Ser phosphorylation site {S664}
References
UniProt :accession Q53G59
Components
G-protein-signaling modulator 2 (mosaic protein LGN, GPSM2, LGN)
lethal(2) giant larvae protein homolog 2 (HGL, LLGL2)
partitioning defective 6 homolog beta (PAR-6 beta, PAR-6B, PARD6B, PAR6B)
protein kinase C-iota (PRKCI, DXS1179E)