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GPI ethanolamine phosphate transferase 2 (phosphatidylinositol-glycan biosynthesis class G protein, PIG-G, GPI7 homolog, hGPI7, PIGG, GPI7, UNQ1930/PRO4405)
Function:
- glycolipid biosynthesis, glycosylphosphatidylinositol- anchor biosynthesis
- ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis
- transfers ethanolamine phosphate to the GPI second mannose
- forms a complex with PIGF which stabilizes PIGG
- competes with PIGO for the binding of PIGF
Structure: belongs to the PIGG/PIGN/PIGO family, PIGG subfamily
Compartment: endoplasmic reticulum membrane
Alternative splicing: named isoforms=5
General
glycoprotein
phosphotransferase
transmembrane 12e protein
Properties
SIZE: MW = 108 kD
entity length = 983 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-431}
MOTIF: N-glycosylation site {N194}
transmembrane domain {432-452}
cytoplasmic loop {453-470}
transmembrane domain {471-491}
exoplasmic loop {492-505}
transmembrane domain {506-526}
cytoplasmic loop {527-551}
transmembrane domain {552-572}
exoplasmic loop {573-698}
transmembrane domain {699-719}
cytoplasmic loop {720-720}
transmembrane domain {721-741}
exoplasmic loop {742-751}
transmembrane domain {752-772}
cytoplasmic loop {773-788}
transmembrane domain {789-809}
exoplasmic loop {810-811}
transmembrane domain {812-832}
cytoplasmic loop {833-878}
transmembrane domain {879-899}
exoplasmic loop {900-918}
transmembrane domain {919-939}
cytoplasmic loop {940-954}
transmembrane domain {955-975}
exoplasmic domain {976-983}
Database Correlations
UniProt Q5H8A4
Pfam PF00884
References
UniProt :accession Q5H8A4