Go protein

Function: - second messengers relaying signals from G-protein-coupled receptors (serpentine receptors) - couples receptors to phospholipase C Structure: - Go-alpha - G-beta/gamma - GDP/GTP complex Expression: - abundant in brain

Properties

COMPARTMENT: plasma membrane* CELL: most cell types* ORGANISM: eukaryote* MOTIF: Mg+2-binding site SUBUNITS: Go-alpha MOTIF: binding site EFFECTOR-BOUND: G-beta/gamma P-loop EFFECTOR-BOUND: guanosine triphosphate Mg+2-binding site ADP-ribosylation site {C350} guanine nucleotide-binding site EFFECTOR-BOUND: guanosine diphosphate ADP-ribosylation site GTP-binding regulatory protein beta MOTIF: WD repeat (8) membrane region Ser phosphorylation site guanine nucleotide binding protein (G protein), gamma subunit MOTIF: CaaX motif SITE: C-TERMINUS QUALITIES: AAX-TRUNCATED CARBOXYMETHYLATED EFFECTOR-BOUND: prenyl BOUND-VIA: cysteine residue

Components

G-beta/gamma Gi-alpha Go-alpha GTP-binding regulatory protein beta guanine nucleotide binding protein (G protein), gamma subunit