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Golgi SNARE complex (Golgi SNAP receptor complex)
Function:
- may function in
a) homotypic fusion of late endosomes
b) heterotypic fusion of late endosomes with lysosomes c lysosomal exocytosis
Structure:
- presumptively SNARE core complex
- may be several different SNARE complexes including complexes containing:
a) Golgi SNAREs GOSR1, GOSR2 & YKT6 & STX5
b) VTI1B, STX7, STX8 & VAMP8
c) STX18, USE1L, BNIP1/SEC20L, & SEC22B
- RINT1/TIP20L & ZW10 are associated with the complex through interaction with BNIP1/SEC20L
d) STX4, SNAP23, VAMP7
e) STX7, STX8, VAMP7 & VTI1B
Related
soluble NSF attachment protein (SNAP)
General
fusion protein
membrane protein
molecular complex
receptor
Properties
COMPARTMENT: golgi
MOTIF: ligand-binding site
FOR-BINDING-OF: alpha-soluble NSF attachment protein
beta-soluble NSF attachment protein
membrane region
allosteric site
FOR-BINDING-OF: gamma-soluble NSF attachment protein
SUBUNITS: Golgi SNAP receptor complex member 1
MOTIF: coiled coil {9-30}
coiled coil {68-95}
transmembrane domain {230-250}
Golgi SNAP receptor complex member 2
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
coiled coil {61-107}
transmembrane domain {191-211}
Vesicular {212-212}
MISC-INFO: LIGAND = SNAP
References
- Sollner T, Whiteheart SW, Brunner M et al
SNAP receptors implicated in vesicle targeting and fusion.
Nature. 1993 Mar 25;362(6418):318-24.
PMID: 8455717
- UniProt :accession Q9P2W9
Components
Golgi SNAP receptor complex member 1; 28 kD Golgi SNARE protein; 28 kD cis-Golgi SNARE p28; GOS-28 (GOSR1, GS28)
Golgi SNAP receptor complex member 2; 27 kD Golgi SNARE protein; membrin (GOSR,2 GS27)