Golgi phosphoprotein 4; Golgi integral membrane protein cis; GIMPc; Golgi-localized phosphoprotein of 130 kD; Golgi phosphoprotein of 130 kD (GOLPH4, GIMPC, GPP130, GOLIM4)

Function: 1) plays a role in endosome to Golgi protein trafficking 2) mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi 3) phosphorylated by c-AMP-dependent kinases in its lumenal part (putative) Structure: - O-glycosylated, modified by sialic acid residues - N-glycosylated, N-glycans are probably of the complex type & modified by sialic acid residues - belongs to the GOLPH4 family Compartment: - Golgi membrane, endosome membrane - localizes to cis & medial Golgi cisternae - probably cycles between early Golgi & endosome

General

glycoprotein membrane protein phosphoprotein

Properties

SIZE: MW = 82 kD entity length = 696 aa COMPARTMENT: golgi MOTIF: transmembrane domain {13-33} coiled coil {35-244} MOTIF: Golgi targeting {38-107} endosome targeting {80-175} Golgi targeting {176-248} N-glycosylation site {N257} glutamate-rich region {311-681} MOTIF: glutamate residue (SEVERAL) Tyr phosphorylation site {Y394} Ser phosphorylation site {S396} glutamine-rich region {404-513} MOTIF: glutamine residue (SEVERAL)

Database Correlations

OMIM 606805 UniProt O00461

References

UniProt :accession O00461