Search
granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor or colony stimulating factor receptor 2
Structure:
- heterodimer of an alpha (CSF2RA) & a beta (KH97) subunit
- the beta subunit (KH97) is common to the
a) IL3 receptor,
b) IL5 receptor
c) GM-CSF receptor
Related
granulocyte-macrophage colony-stimulating factor; GM-CSF; colony-stimulating factor 2; molgramostin; sargramostim (CSF2, GMCSF)
General
colony-stimulating factor [CSF] receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: ligand-binding site
transmembrane domain
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
SUBUNITS: GM-CSF receptor-alpha
MOTIF: signal sequence {1-22}
N-glycosylation site {N46}
N-glycosylation site {N54}
N-glycosylation site {N99}
N-glycosylation site {N123}
cysteine residue {C126}
MODIFICATION: cysteine residue {C136}
N-glycosylation site {N135}
cysteine residue {C136}
MODIFICATION: cysteine residue {C126}
cysteine residue {C165}
MODIFICATION: cysteine residue {C178}
cysteine residue {C178}
MODIFICATION: cysteine residue {C165}
N-glycosylation site {N182}
N-glycosylation site {N195}
N-glycosylation site {N223}
N-glycosylation site {N229}
N-glycosylation site {N272}
N-glycosylation site {N305}
WSXWS motif {306-310}
transmembrane domain {321-346}
box1 motif
SITE: 355-363
FOR-BINDING-OF: Janus kinase (JAK)
cytokine receptor common subunit beta
MOTIF: signal sequence {1-16}
cysteine residue {C35}
MODIFICATION: cysteine residue {C45}
cysteine residue {C45}
MODIFICATION: cysteine residue {C35}
N-glycosylation site {N58}
cysteine residue {C75}
MODIFICATION: cysteine residue {C96}
cysteine residue {C86}
MODIFICATION: cysteine residue {C91}
cysteine residue {C91}
MODIFICATION: cysteine residue {C86}
cysteine residue {C96}
MODIFICATION: cysteine residue {C75}
fibronectin type III domain or F3 module {133-233}
MOTIF: N-glycosylation site {N191}
cysteine residue {C250}
MODIFICATION: cysteine residue {C260}
cysteine residue {C260}
MODIFICATION: cysteine residue {C250}
cysteine residue {C289}
MODIFICATION: cysteine residue {C306}
cysteine residue {C306}
MODIFICATION: cysteine residue {C289}
fibronectin type III domain or F3 module {338-432}
MOTIF: N-glycosylation site {N346}
WSXWS motif {425-429}
transmembrane domain {444-460}
box1 motif
SITE: 474-482
FOR-BINDING-OF: Janus Kinase 2 (JAK2)
Tyr phosphorylation site {Y766}
Database Correlations
OMIM 306250
References
- Taga T & Kishimoto T
Cytokine receptors and signal transduction
FASEB J 6:3387 1992
PMID: 1334470
- OMIM 306250
Components
CDw116; granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF receptor-alpha; GM-CSF-R-alpha; GMR;CD116 (CSF2RA, CSF2R, CSF2RY)
CDw131; cytokine receptor common subunit beta; KH97; GM-CSF/IL-3/IL-5 receptor common beta-chain; CDw131; CD131 (CSF2RB, IL3RB, IL5RB)