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GMP synthase [glutamine-hydrolyzing]; GMP synthetase; glutamine amidotransferase (GMPS)
Function:
- role in the de novo synthesis of guanine nucleotides
- essential for DNA & RNA synthesis
- essential for providing GTP
- purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1
ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate
Structure:
- homodimer (putative)
- contains 1 glutamine amidotransferase type-1 domain
- contains 1 GMP-binding domain
Compartment: cytoplasm
Pathology:
- chromosomal translocation t(3,11)(q25,q23) involving GMPS with MLL is found in acute myeloid leukemias
General
ligase or synthetase
phosphoprotein
Properties
SIZE: entity length = 693 aa
MW = 77 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Glutamine amidotransferase type-1 {27-216}
MOTIF: cysteine residue {C104}
histidine residue {H190}
glutamate residue {E192}
ATP-binding site
NAME: ATP-binding site
SITE: 244-250
Thr phosphorylation site {T318}
Ser phosphorylation site {S332}
Database Correlations
OMIM 600358
UniProt P49915
PFAM correlations
Entrez Gene 8833
Kegg hsa:8833
ENZYME 6.3.5.2
References
- UniProt :accession P49915
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GMPSID229.html