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glypican-3; intestinal protein OCI-5; GTR2-2; MXR7; (GPC3, OCI5)
Function:
- cell surface proteoglycan that bears heparan sulfate
- may be involved in the suppression/modulation of growth in predominantly mesodermal tissues & organs
- may play a role in modulation of IGF2 function
- may regulate growth & tumor predisposition
Structure: belongs to the glypican family
Compartment:
- cell membrane; lipid-anchor
- GPI-anchor extracellular side (putative)
- secreted, extracellular space (putative)
Expression: highly expressed in lung, liver & kidney
Pathology:
- defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome
General
glypican
Properties
SIZE: entity length = 580 aa
MW = 66 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-24}
N-glycosylation site {N124}
N-glycosylation site {N241}
N-glycosylation site {N418}
Ser glycosylation site {S495}
Ser glycosylation site {S509}
Database Correlations
OMIM correlations
MORBIDMAP 300037
UniProt P51654
Pfam PF01153
Entrez Gene 2719
Kegg hsa:2719
References
- UniProt :accession P51654
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GPC3ID156.html
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GPC3