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glypiated protein

Glycosylphosphatidylinositol (GPI)-anchored protein. Glypiated proteins are initially directed towards the secretory pathway by means of an NH2-terminal sequence, where the acquire the GPI moiety (3). The GPI moiety is preassembled on the cytoplasmic face of the ER & then transferred into the lumen where it is attached to the COOH-terminal residue of the protein.

Related

glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1 (GPAA1, GAA1)

Specific

alkaline phosphatase alkaline phosphatase, placental type 1 (regan isozyme, ALPP, PLAP) alkaline phosphatase, placental-like 2 (germ-cell alkaline phosphatase, NAGAO isozyme, GCAP, PLAP-like, ALP-1, ALPPL2, ALPPL) alkaline phosphatase-I; intestinal alkaline phosphatase; IAP (ALPI) alkaline phosphatase-L (liver/kidney/bone, tissue-nonspecific alkaline phosphatase, ALPL) angiotensin converting enzyme (ACE) bone marrow stromal antigen 2; BST-2; tetherin; HM1.24 antigen; CD317 (BST2) brevican core protein (brain-enriched hyaluronan-binding protein, protein BEHAB, BCAN, BEHAB, CSPG7, UNQ2525/PRO6018) cadherin-13; Truncated cadherin; T-cadherin; T-cad; heart cadherin; H-cadherin; P105 (CDH13, CDHH) carbonic anhydrase-4 (CA4) carboxypeptidase M (CPM) carcinoembryonic antigen-related cell adhesion molecule 6; normal cross-reacting antigen; non-specific crossreacting antigen; CD66c (CEACAM6 NCA) carcinoembryonic antigen-related cell adhesion molecule 7; carcinoembryonic antigen CGM2 (CEACAM7, CGM2) CD109 antigen; C3 & PZP-like alpha-2-macroglobulin domain-containing protein 7; 150 kD TGF-beta-1-binding protein; platelet-specific Gov antigen; human platelet antigen 15; HPA-15; p180; r150 (CD109, CPAMD7) CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein CD157; ADP-ribosyl cyclase 2; cyclic ADP-ribose hydrolase 2; bone marrow stromal antigen 1 (BST1) CD160 antigen; natural killer cell receptor BY55 (CD160, BY55) CD16b; low affinity immunoglobulin gamma Fc region receptor III-B; IgG Fc receptor III-1; Fc-gamma RIII-beta; Fc-gamma RIIIb; FcRIIIb; Fc-gamma RIII; FcRIII; FcR-10 (FCGR3B CD16B FCG3 FCGR3 IGFR3) CD177 (polycythemia rubra vera protein 1, PRV-1, NB1 glycoprotein, NB1 GP, human neutrophil alloantigen 2a, HNA-2a, NB1, PRV1, UNQ595/PRO1181) CD24; signal transducer CD24; small cell lung carcinoma cluster 4 antigen (CD24, CD24A) CD48; B-lymphocyte activation marker BLAST-1; BCM1 surface antigen; Leukocyte antigen MEM-102; TCT.1 (BCM1, BLAST1) CD52; CAMPATH-1 antigen; Cambridge pathology 1 antigen; epididymal secretory protein E5; CDw52 (CDW52, HE5) CD55; complement decay accelerating factor (DAF) CD59; CD59 glycoprotein; membrane attack complex inhibition factor; MACIF; MAC-inhibitory protein; MAC-IP; protectin; MEM43 antigen; membrane inhibitor of reactive lysis; MIRL; 20 kD homologous restriction factor; HRF-20; HRF20; 1F5 antigen (MIC11, MIN1, MIN2, MIN3, MSK21) CD66b; carcinoembryonic antigen-related cell adhesion molecule 8; carcinoembryonic antigen CGM6; non-specific cross-reacting antigen NCA-95; CD67 antigen (CEACAM8, CGM6) CD66e; carcinoembryonic antigen-related cell adhesion molecule 5; carcinoembryonic antigen; CEA; meconium antigen 100; CD66e (CEACAM5, CEA) CD73 (ecto-5'nucleotidase, 5-prime-ribonucleotide phosphohydrolase, NT5E) CD90; thy-1 membrane glycoprotein; thy-1 antigen; CDw90 (THY1) ciliary neurotrophic factor receptor alpha; CNTFR alpha (CNTFR) contactin cryptic protein; cryptic family protein 1 (CFC1) dipeptidase 2 (DPEP2) ecto-ADP-ribosyltransferase 3; mono(ADP-ribosyl)transferase 3; NADP+-arginine ADP-ribosyltransferase 3 (ART3, TMART) ecto-ADP-ribosyltransferase 4; Dombrock blood group carrier molecule; mono(ADP-ribosyl)transferase 4; NADP+-arginine ADP-ribosyltransferase 4; CD297 (ART4, DO, DOK1) ephrin A or ephrin A ligand folate receptor or folate-binding protein GDNF family receptor alpha-4 (GFR-alpha-4, persephin receptor, GFRA4) glial derived neurotrophic factor [GDNF] receptor alpha glycosyl-phosphatidylinositol-anchored molecule-like protein (GML LY6DL) glypican GPI-anchored membrane protein 1; GPI-anchored protein p137; p137GPI; membrane component chromosome 11 surface marker 1 (GPIAP1, GPIP137, M11S1, CAPRIN1) GPI-linked NADP+-arginine ADP-ribosyltransferase 1; mono(ADP-ribosyl)transferase 1; CD296 (ART1) growth arrest-specific protein 1; GAS-1 (GAS1) hyaluronidase PH-20; hyal-PH20; hyaluronoglucosaminidase PH-20; sperm adhesion molecule 1; sperm surface protein PH-20 (SPAM1 HYAL3 PH20) hyaluronidase-2; hyal-2; hyaluronoglucosaminidase-2; lung carcinoma protein 2; LuCa-2 (HYAL2, LUCA2) intelectin-1 (intestinal lactoferrin receptor, galactofuranose-binding lectin, endothelial lectin HL-1, omentin, ITLN1, INTL, ITLN, LFR, UNQ640/PRO1270) limbic system-associated membrane protein (LSAMP, LAMP) Ly-6/neurotoxin-like protein 1;endogenous prototoxin LYNX1; testicular tissue protein Li 112 (LYNX1) Ly6/PLAUR domain-containing protein 1 (HeLa tumor suppressor, PHTS, LYPD1, LYPDC1, PSEC0181, UNQ3079/PRO9917) Ly6/PLAUR domain-containing protein 3 (GPI-anchored metastasis-associated protein C4.4A homolog, matrigel-induced gene C4 protein, MIG-C4, LYPD3, C44A, UNQ491/PRO1007) Ly6/PLAUR domain-containing protein 4 (LYPD4) Ly6/PLAUR domain-containing protein 5 (LYPD5, LYPDC5, UNQ1908/PRO4356) lymphocyte antigen 6 complex locus protein G6d; protein Ly6-D; megakaryocyte-enhanced gene transcript 1 protein (LY6G6D, C6orf23, G6D, MEGT1, NG25) lymphocyte antigen 6K (Ly-6K, LY6K, CO16) lymphocyte antigen 6L; lymphocyte antigen 6 complex locus protein L (LY6L) lymphocyte antigen 6S (LY6S) lymphocyte antigen Ly-6D (E48 antigen, LY6D, E48) lymphocyte antigen Ly-6E (retinoic acid-induced gene E protein, RIG-E, thymic shared antigen 1, TSA-1, stem cell antigen 2, SCA-2) lymphocyte antigen Ly-6H (LY6H) MAM domain-containing glycosylphosphatidylinositol anchor protein 1; GPI & MAM protein; GPIM; glycosylphosphatidylinositol-MAM; MAM domain-containing protein 3 (MDGA1, MAMDC3) MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain-containing protein 1 (MDGA2, MAMDC1, UNQ8188/PRO23197) mesothelin; CAK1 antigen; pre-pro-megakaryocyte-potentiating factor; contains: megakaryocyte-potentiating factor; MPF; mesothelin, cleaved form (MSLN, MPF) netrin G1 (laminet-1, NTNG1, KIAA0976, LMNT1, UNQ571/PRO1133) netrin G2 (laminet-2, NTNG2, KIAA1857, LMNT2, UNQ9381/PRO34206) neuritin (NRN1) neuronal growth regulator 1 (NEGR1) NKG2D ligand (NKG2D) oligodendrocyte-myelin glycoprotein (OMG OMGP) opioid-binding protein/cell adhesion molecule (OBCAM, opioid-binding cell adhesion molecule, OPCML) otoancorin pancreatic secretory granule membrane major glycoprotein GP2; pancreatic zymogen granule membrane protein GP-2 (ZAP75) pantetheinase (pantetheine hydrolase, vascular non-inflammatory molecule 1, Vanin-1, Tiff66, VNN1) prostate stem cell antigen (PSCA) protein UNQ511/PRO1026 (LYPD8) renal dipeptidase; microsomal dipeptidase; dipeptidase 1 (DPEP1, MDP, RDP) repulsive guidance molecule (RGM) family (RGM domain family) reticulon-4 receptor-like 1 (Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 3, NgR3, Nogo receptor-like 2, RTN4RL1, NGRH2, NGRL2) reticulon-4 receptor-like 2 (Nogo-66 receptor homolog 2, Nogo-66 receptor-related protein 2, NgR2, Nogo receptor-like 3, RTN4RL2, NGRH1, NGRL3) reticulon-4 receptor; Nogo receptor; NgR; Nogo-66 receptor (RTN4R, NOGOR, UNQ330/PRO526) reversion-inducing cysteine-rich protein with Kazal motifs (hRECK, suppressor of tumorigenicity 15, ST15, RECK) semaphorin-7A; semaphorin-L; sema L; semaphorin-K1; sema K1; John-Milton-Hargen human blood group Ag; JMH blood group antigen; CDw108; CD108 (SEMA7A, CD108, SEMAL) sperm acrosome membrane-associated protein 4; sperm acrosomal membrane-associated protein 14 (SPACA4, SAMP14, UNQ3046/PRO9862) tectorin teratocarcinoma-derived growth factor 1; cripto-1 growth factor; CRGF; EGF-like cripto protein CR1 (TDGF1, CRIPTO) testis serine protease 1; TESSP-1 (TESSP1, PRSS41) testis-expressed protein 101 (scleroderma-associated autoantigen, cell surface receptor NYD-SP8, spermatogenesis-related gene protein, TEX101, SGRG, UNQ867/PRO1884) testisin; eosinophil serine protease 1; ESP-1; serine protease 21 (PRSS21, ESP1, TEST1, UNQ266/PRO303) trehalase (alpha,alpha-trehalose glucohydrolase, TREH, TREA) urokinase plasminogen activator surface receptor; uPAR; U-PAR; monocyte activation antigen Mo3; CD87 (PLAUR, MO3, UPAR) uromodulin; Tamm-Horsfall urinary glycoprotein; THP (UMOD) vascular non-inflammatory molecule 2 (vanin-2, glycosylphosphatidyl inositol-anchored protein GPI-80, protein FOAP-4, VNN2) vascular non-inflammatory molecule 3 (Vanin-3, VNN3) Xaa-Pro aminopeptidase 2; aminoacylproline aminopeptidase; membrane-bound aminopeptidase P; membrane-bound APP; membrane-bound AmP; mAmP; X-Pro aminopeptidase 2 (XPNPEP2)

General

glycoprotein plasma membrane protein

Properties

COMPARTMENT: plasma membrane CELL-REGION: apical region CELL: epithelial cell MOTIF: glycosyl phosphatidylinositol [GPI] membrane anchor {C-TERMINUS}

Database Correlations

Kegg map/map00563

References

  1. Dotti et al Nature 349:158 1991
  2. Low et al TIBS 11 212 1986
  3. Casey PJ Protein lipidation in cell signaling. Science 268:221 1995 PMID: 7716512