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glyoxylate reductase/hydroxypyruvate reductasel D-glycerate dehydrogenase; D-glyceric dehydrogenase (GRHPR, GLXR, MSTP035)
Function:
- enzyme with hydroxy-pyruvate reductase, glyoxylate reductase & D-glycerate dehydrogenase enzymatic activities
Glycolate + NADP+ glyoxylate + NADPH
Structure:
- monomer
- belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Expression:
- ubiquitous
- most abundantly expressed in the liver
Pathology:
- defects in GRHPR are the cause of primary hyperoxaluria type 2
Laboratory:
- GRHPR gene mutation
General
enzyme
Properties
SIZE: MW = 36 kD
entity length = 328 aa
MOTIF: arginine residue {R245}
glutamate residue {E274}
histidine residue {H293}
Database Correlations
OMIM correlations
MORBIDMAP 604296
UniProt Q9UBQ7
PFAM correlations
ENZYME 1.1.1.79
References
- UniProt :accession Q9UBQ7
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GRHPR