glycosyltransferase 25 family member 1; procollagen galactosyltransferase 1; collagen beta(1-O)galactosyltransferase 1; hydroxylysine galactosyltransferase 1 (COLGALT1, GLT25D1, PSEC0241)

Function: - beta-galactosyltransferase activity - transfers beta-galactose to hydroxylysine residues of collagen - has no glucosyltransferase activity UDP-alpha-D-galactose + 5-hydroxy-L-lysine-[procollagen] = UDP + 5-(D-galactosyloxy)-L-lysine-[procollagen] Kinetic parameters: - KM=18.7 uM for UDP-galactose Structure: - N-glycosylated - belongs to the glycosyltransferase 25 family Compartment: - endoplasmic reticulum lumen (putative) - colocalized with PLOD3 & mannose binding lectin Expression: - ubiquitous - higher levels in placenta, heart, lung & spleen

General

galactosyltransferase glycoprotein

Properties

SIZE: entity length = 622 aa MW = 72 kD COMPARTMENT: endoplasmic reticulum MOTIF: signal sequence {1-29} N-glycosylation site {N96} N-glycosylation site {N184} N-glycosylation site {N381} Prevents secretion from ER {619-622}

Database Correlations

UniProt Q8NBJ5 Pfam PF01755 Entrez Gene 79709 Kegg hsa:79709 ENZYME 2.4.1.50

References

UniProt :accession Q8NBJ5