glycosylphosphatidylinositol anchor attachment 1 protein; GPI anchor attachment protein 1; GAA1 protein homolog; hGAA1 (GPAA1, GAA1)

Function: - essential for GPI-anchoring of precursor proteins - not essential for GPI synthesis - acts before or during formation of the carbonyl intermediate - glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis - forms a complex with PIGK/GPI8, PIGT, PIGU & PIGS Compartment: - endoplasmic reticulum membrane; multi-pass membrane protein Alternative splicing: named isoforms=2 Expression: - ubiquitously expressed in fetal & adult tissues - expressed at higher levels in fetal tissues than adult tissues

General

glycoprotein transmembrane 7c protein

Properties

SIZE: MW = 67 kD entity length = 620 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-23} transmembrane domain {24-44} exoplasmic loop {45-367} MOTIF: N-glycosylation site {N202} transmembrane domain {368-388} cytoplasmic loop {389-426} transmembrane domain {427-447} exoplasmic loop {448-457} transmembrane domain {458-478} cytoplasmic loop {479-494} transmembrane domain {495-515} exoplasmic loop {516-542} MOTIF: N-glycosylation site {N516} transmembrane domain {543-563} cytoplasmic loop {564-598} transmembrane domain {599-619} exoplasmic domain {620-620}

Database Correlations

OMIM 603048 UniProt O43292 Pfam PF04114 Entrez Gene 8733 Kegg hsa:8733

References

UniProt :accession O43292