ammonium transporter Rh type A; Rhesus blood group family type A glycoprotein; Rh family type A glycoprotein; Rh type A glycoprotein; Rhesus blood group-associated glycoprotein; Rhesus blood group-associated ammonia channel; erythrocyte membrane glycoprotein Rh50; erythrocyte plasma membrane 50 kD glycoprotein; Rh50A; CD241 (RHAG, RH50)

Function: - associated with rhesus blood group antigen expression - may be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane - heterotetramer Structure: - belongs to the ammonium transporter (TC 2.A.49) family, Rh subfamily Compartment: membrane Expression: erythrocytes Pathology: - defects in RHAG are the cause of regulator type Rh-null hemolytic anemia

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein transmembrane 12 protein

Properties

SIZE: entity length = 409 aa MW = 44 kD COMPARTMENT: plasma membrane MOTIF: cytoplasmic domain {1-2} transmembrane domain {3-23} exoplasmic loop {24-51} MOTIF: N-glycosylation site {N37} transmembrane domain {52-72} cytoplasmic loop {73-79} transmembrane domain {80-100} exoplasmic loop {101-113} transmembrane domain {114-134} cytoplasmic loop {135-142} transmembrane domain {143-163} exoplasmic loop {164-167} transmembrane domain {168-188} cytoplasmic loop {189-208} transmembrane domain {209-229} exoplasmic loop {230-239} transmembrane domain {240-260} cytoplasmic loop {261-268} transmembrane domain {269-291} exoplasmic loop {292-295} transmembrane domain {296-318} cytoplasmic loop {319-332} transmembrane domain {333-353} exoplasmic loop {354-362} MOTIF: N-glycosylation site {N355} transmembrane domain {363-383} cytoplasmic domain {384-409}

Database Correlations

OMIM correlations MORBIDMAP 180297 UniProt Q02094 Pfam PF00909 Entrez Gene 6005 Kegg hsa:6005

References

UniProt :accession Q02094