glycoprotein IIB/IIIA selections

glycoprotein IIB/IIIA

Mediates platelet aggregation through binding of fibrinogen. Weak intercellular bridges are established via multiple platelets binding the same fibrinogen molecule.

abciximab (ReoPro) Eptifibatide (Integrilin) fibrinogen; coagulation factor-1 fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN) platelet platelet glycoprotein IIb/IIIa Ab in blood platelet glycoprotein IIb/IIIa Ab in serum platelet glycoprotein IIb/IIIa IgG in blood platelet glycoprotein IV Ab in serum Tirofiban (Aggrastat) vitronectin; S-protein; serum-spreading factor; V75; contains: vitronectin V65 subunit; vitronectin V10 subunit; somatomedin-B (VTN) von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)

General

integrin

Properties

COMPARTMENT: plasma membrane CELL: platelet MOTIF: focal adhesion site transmembrane domain SUBUNITS: integrin alpha-IIb MOTIF: signal sequence {1-31} N-glycosylation site {N46} FG-GAP {47-107} MOTIF: cysteine residue {C87} MODIFICATION: cysteine residue {C96} cysteine residue {C96} MODIFICATION: cysteine residue {C87} consensus repeat {108} SEQUENCE-IS: FG-GAP cysteine residue {C138} MODIFICATION: cysteine residue {C161} cysteine residue {C161} MODIFICATION: cysteine residue {C138} cysteine residue {C177} MODIFICATION: cysteine residue {C198} cysteine residue {C198} MODIFICATION: cysteine residue {C177} consensus repeat {262} SEQUENCE-IS: FG-GAP FG-GAP {263-316} MOTIF: Ca+2-binding site SITE: 274-282 N-glycosylation site {N280} FG-GAP {317-384} MOTIF: Ca+2-binding site SITE: 328-336 FG-GAP {385-444} MOTIF: Ca+2-binding site SITE: 396-404 FG-GAP {445-497} MOTIF: Ca+2-binding site SITE: 457-465 cysteine residue {C504} MODIFICATION: cysteine residue {C515} cysteine residue {C515} MODIFICATION: cysteine residue {C504} cysteine residue {C521} MODIFICATION: cysteine residue {C576} cysteine residue {C576} MODIFICATION: cysteine residue {C521} N-glycosylation site {N601} cysteine residue {C633} MODIFICATION: cysteine residue {C639} cysteine residue {C639} MODIFICATION: cysteine residue {C633} cysteine residue {C705} MODIFICATION: cysteine residue {C718} N-glycosylation site {N711} cysteine residue {C718} MODIFICATION: cysteine residue {C705} cysteine residue {C857} MODIFICATION: cysteine residue {C-INTERCHAIN} Ser glycosylation site {S878} cysteine residue {C916} MODIFICATION: cysteine residue {C921} cysteine residue {C921} MODIFICATION: cysteine residue {C916} N-glycosylation site {N962} transmembrane domain {994-1019} GFFKR {1022-1026} integrin-beta 3 MOTIF: signal sequence {1-26} cysteine residue {C31} MODIFICATION: cysteine residue {C461} cysteine residue {C39} MODIFICATION: cysteine residue {C49} cysteine residue {C42} MODIFICATION: cysteine residue {C75} cysteine residue {C49} MODIFICATION: cysteine residue {C39} cysteine residue {C52} MODIFICATION: cysteine residue {C64} cysteine residue {C64} MODIFICATION: cysteine residue {C52} cysteine residue {C75} MODIFICATION: cysteine residue {C42} N-glycosylation site {N125} VWFA domain {135-377} MOTIF: cysteine residue {C203} MODIFICATION: cysteine residue {C210} cysteine residue {C210} MODIFICATION: cysteine residue {C203} cysteine residue {C258} MODIFICATION: cysteine residue {C299} cysteine residue {C299} MODIFICATION: cysteine residue {C258} N-glycosylation site {N346} N-glycosylation site {N397} cysteine residue {C400} MODIFICATION: cysteine residue {C412} cysteine residue {C412} MODIFICATION: cysteine residue {C400} cysteine residue {C432} MODIFICATION: cysteine residue {C681} cysteine residue {C459} MODIFICATION: cysteine residue {C463} cysteine residue {C461} MODIFICATION: cysteine residue {C31} Cysteine-rich tandem repeats {463-629} MOTIF: consensus repeat {463-511} cysteine residue {C463} MODIFICATION: cysteine residue {C459} cysteine residue {C474} MODIFICATION: cysteine residue {C486} N-glycosylation site {N478} cysteine residue {C483} MODIFICATION: cysteine residue {C521} cysteine residue {C486} MODIFICATION: cysteine residue {C474} cysteine residue {C488} MODIFICATION: cysteine residue {C497} cysteine residue {C497} MODIFICATION: cysteine residue {C488} cysteine residue {C499} MODIFICATION: cysteine residue {C512} consensus repeat {512-553} cysteine residue {C512} MODIFICATION: cysteine residue {C499} cysteine residue {C521} MODIFICATION: cysteine residue {C483} cysteine residue {C527} MODIFICATION: cysteine residue {C532} cysteine residue {C529} MODIFICATION: cysteine residue {C562} cysteine residue {C532} MODIFICATION: cysteine residue {C527} cysteine residue {C534} MODIFICATION: cysteine residue {C547} cysteine residue {C547} MODIFICATION: cysteine residue {C534} cysteine residue {C549} MODIFICATION: cysteine residue {C554} consensus repeat {554-592} cysteine residue {C554} MODIFICATION: cysteine residue {C549} cysteine residue {C562} MODIFICATION: cysteine residue {C529} cysteine residue {C568} MODIFICATION: cysteine residue {C573} cysteine residue {C570} MODIFICATION: cysteine residue {C601} cysteine residue {C573} MODIFICATION: cysteine residue {C568} cysteine residue {C575} MODIFICATION: cysteine residue {C584} cysteine residue {C584} MODIFICATION: cysteine residue {C575} N-glycosylation site {N585} cysteine residue {C586} MODIFICATION: cysteine residue {C593} consensus repeat {593-629} cysteine residue {C593} MODIFICATION: cysteine residue {C586} cysteine residue {C601} MODIFICATION: cysteine residue {C570} cysteine residue {C607} MODIFICATION: cysteine residue {C612} cysteine residue {C609} MODIFICATION: cysteine residue {C657} cysteine residue {C612} MODIFICATION: cysteine residue {C607} cysteine residue {C614} MODIFICATION: cysteine residue {C624} cysteine residue {C624} MODIFICATION: cysteine residue {C614} cysteine residue {C627} MODIFICATION: cysteine residue {C630} cysteine residue {C630} MODIFICATION: cysteine residue {C627} cysteine residue {C634} MODIFICATION: cysteine residue {C643} cysteine residue {C640} MODIFICATION: cysteine residue {C713} cysteine residue {C643} MODIFICATION: cysteine residue {C634} cysteine residue {C657} MODIFICATION: cysteine residue {C609} cysteine residue {C661} MODIFICATION: cysteine residue {C689} N-glycosylation site {N680} cysteine residue {C681} MODIFICATION: cysteine residue {C432} cysteine residue {C689} MODIFICATION: cysteine residue {C661} cysteine residue {C713} MODIFICATION: cysteine residue {C640} transmembrane domain {719-741} Tyr phosphorylation site {Y773} Thr phosphorylation site {T779} Tyr phosphorylation site {Y785} MISC-INFO: LIGAND = FIBRONECTIN LIGAND = FIBRINOGEN LIGAND = VITRONECTIN LIGAND = VWF

References

Molecular Cell Biology (2nd ed) Darnell J; Lodish H & Baltimore D (eds), Scientific American Books, WH Freeman, NY 1990, pg 921
Fibrinolysis, Thrombosis, & Hemostasis: Concepts, Perspectives, and Clinical Applications. S Sherry, Lea & Febiger, Philadelphia, 1992, pg 73,74,80

Components

CD41; integrin alpha-IIb; platelet membrane glycoprotein IIb (ITGA2B, GP2B, ITGAB) CD61 (integrin-beta 3, platelet membrane glycoprotein IIIA, GPIIIA, ITGB3, GP3A)

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