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glycoprotein-Ib-V-IX complex
Function:
- receptor for von willebrand factor (vWF) on cell surface of platelets
- receptor for thrombin
- actual binding site is on glycoprotein 1b-alpha
- mediates vWF-dependent platelet adhesion to blood vessels
- adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis
Structure:
- subunits:
- glycoprotein-Ib
- GP-Ib alpha & GP-Ib beta are disulfide linked
- glycoprotein-V
- glycoprotein-IX
Compartment:
- plasma membrane of platelets
Related
von Willebrand factor; vWF; ristocetin cofactor; factor VIII related antigen; contains: von Willebrand antigen 2 (VWF, F8VWF)
General
adhesion receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: focal adhesion site
transmembrane domain
SUBUNITS: platelet glycoprotein 1b
MOTIF: focal adhesion site
transmembrane domain
platelet glycoprotein V
MOTIF: signal sequence {1-16}
N-glycosylation site {N51}
leucine-rich repeat
SITE: 73-96
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 97-120
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 122-144
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 145-168
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 169-192
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N181}
leucine-rich repeat
SITE: 194-216
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 217-240
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 241-264
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N243}
leucine-rich repeat
SITE: 266-288
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N267}
leucine-rich repeat
SITE: 289-312
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N298}
N-glycosylation site {N312}
leucine-rich repeat
SITE: 314-337
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 338-361
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 362-385
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N385}
leucine-rich repeat
SITE: 386-409
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N499}
transmembrane domain {524-544}
platelet glycoprotein IX
MOTIF: signal sequence {1-16}
leucine-rich repeat
SITE: 56-79
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N60}
transmembrane domain {152-171}
References
UniProt :accession P14770
Components
CD42a; platelet glycoprotein IX; GPIX (GP9)
CD42D; platelet glycoprotein V; GPV (GP5)
platelet glycoprotein 1b