glycoprotein hormone beta 5 (thyrostimulin beta subunit, GPHB5, GPB5, ZLUT1)

Function: - stimulates the thyroid - binds & activates THSR, leading to increased cAMP production - heterodimer with GPHA2 Structure: - N-glycosylated - belongs to the glycoprotein hormones subunit beta family Compartment: secreted Expression: - highly expressed in brain & at low levels in pituitary - also found in retina, testis & skin - not expressed in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid or adrenal gland - in pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs

Properties

SIZE: MW = 14 kD entity length = 130 aa MOTIF: signal sequence {1-24} cysteine residue {C36} MODIFICATION: cysteine residue {C84} cysteine residue {C50} MODIFICATION: cysteine residue {C99} cysteine residue {C60} MODIFICATION: cysteine residue {C115} cysteine residue {C64} MODIFICATION: cysteine residue {C117} cysteine residue {C84} MODIFICATION: cysteine residue {C36} N-glycosylation site {N87} cysteine residue {C99} MODIFICATION: cysteine residue {C50} cysteine residue {C115} MODIFICATION: cysteine residue {C60} cysteine residue {C117} MODIFICATION: cysteine residue {C64} cysteine residue {C120} MODIFICATION: cysteine residue {C127} cysteine residue {C127} MODIFICATION: cysteine residue {C120}

Database Correlations

UniProt Q86YW7 Pfam PF00007

References

UniProt :accession Q86YW7