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tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; glycoprotein Gp34; TAX transcriptionally-activated glycoprotein 1; CD252 (TNFSF4, TXGP1)
Function:
- cytokine that binds to TNFRSF4
- co-stimulates T-cell proliferation & cytokine production
Structure:
- homotrimer
- belongs to the tumor necrosis factor family
Compartment: membrane; single-pass type 2 membrane protein
Expression:
- induced by human T-cell leukemia virus type 1 transactivator P40-TAX
Pathology:
- genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tumor necrosis factor (TNF) family protein
Properties
SIZE: entity length = 183 aa
MW = 21 kD
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {24-50}
N-glycosylation site {N90}
cysteine residue {C97}
MODIFICATION: cysteine residue {C181}
N-glycosylation site {N114}
N-glycosylation site {N152}
N-glycosylation site {N157}
cysteine residue {C181}
MODIFICATION: cysteine residue {C97}
Database Correlations
OMIM correlations
UniProt P23510
Pfam PF00229
Entrez Gene 7292
Kegg hsa:7292
References
- UniProt :accession P23510
- Entrez Gene :accession 7292