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glycophorin-C; PAS-2'; glycoprotein beta; GLPC; glycoconnectin; sialoglycoprotein D; glycophorin-D; GPD; CD236 (GYPC, GPC)
Function:
- minor sialoglycoprotein in human erythrocyte membranes
- role in regulating the stability of red cells
Structure:
- the blood group Gerbich antigens & receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain
Compartment:
- cell membrane
- linked to the membrane via Band 4.1
Alternative splicing: named isoforms=2; glycophorin C; glycophorin D
Expression:
- glycophorin C is expressed in erythrocytes
- glycophorin D is ubiquitous
Polymorphism:
- GYPC is responsible for the Gerbich blood group system
Pathology:
- receptor for Plasmodium falciparum merozoites
Related
Gerbich blood group locus
General
glycophorin
Properties
SIZE: entity length = 128 aa
MW = 14 kD
COMPARTMENT: cellular membrane
MOTIF: Ser glycosylation site {S3}
Thr glycosylation site {T4}
Ser glycosylation site {S6}
asparagine residue {8}
N-glycosylation site {N8}
Ser glycosylation site {S9}
Thr glycosylation site {T10}
Ser glycosylation site {S15}
Ser glycosylation site {S24}
Ser glycosylation site {S26}
Thr glycosylation site {T27}
Thr glycosylation site {T28}
Thr glycosylation site {T31}
Thr glycosylation site {T32}
Thr glycosylation site {T33}
Ser glycosylation site {S42}
transmembrane domain {58-81}
Database Correlations
OMIM 110750
UniProt P04921
Entrez Gene 2995
Kegg hsa:2995
References
- UniProt :accession P04921
- BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=gerbich
- Wikipedia; Note: glycophorin C entry
http://en.wikipedia.org/wiki/glycophorin_C
- SeattleSNPs
http://pga.gs.washington.edu/data/gypc/