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glycophorin-B; PAS-3; sialoglycoprotein delta; SS-active sialoglycoprotein; CD235b (GYPB, GPB)
Function:
- minor sialoglycoprotein in erythrocyte membranes
Structure:
- O-glycosylated: the N-terminal extracellular domain is heavily glycosylated on Ser & Thr
- belongs to the glycophorin A family
Compartment: membrane
Polymorphism:
- along with GYPA, GYPB is responsible for the MNS blood group
- the molecular basis of the S/s blood group antigen is a single variation in position 48; Thr-48 corresponds to s=MSN4 & Met-48 to S=MNS3
Related
Ss blood group locus
General
glycophorin
Properties
SIZE: entity length = 91 aa
MW = 10 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
serine residue {33}
serine residue {34}
Thr glycosylation site {T36}
Ser glycosylation site {S38}
transmembrane domain {60-81}
Database Correlations
OMIM 111740
UniProt P06028
Pfam PF01102
Entrez Gene 2994
Kegg hsa:2994
References
- UniProt :accession P06028
- BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=mns