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glycine receptor subunit beta; glycine receptor 58 kD subunit (GLRB)
Function:
- glycine receptor beta subunit
- interacts with GPHN (putative)
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9)family
Compartment:
- cell junction, synapse, postsynaptic membrane
Pathology:
- defects in GLRB are a cause of startle disease
General
glycoprotein
protein subunit
transmembrane 4 protein
Properties
SIZE: entity length = 497 aa
MW = 56 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-265}
MOTIF: signal sequence {1-22}
N-glycosylation site {N54}
cysteine residue {C183}
MODIFICATION: cysteine residue {C197}
cysteine residue {C197}
MODIFICATION: cysteine residue {C183}
N-glycosylation site {N242}
transmembrane domain {266-290}
cytoplasmic loop {291-298}
transmembrane domain {299-316}
exoplasmic loop {317-330}
transmembrane domain {331-354}
cytoplasmic loop {355-478}
transmembrane domain {479-496}
exoplasmic domain {497-497}
Database Correlations
OMIM correlations
MORBIDMAP 138492
UniProt P48167
PFAM correlations
Entrez Gene 2743
Kegg hsa:2743
References
- UniProt :accession P48167
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GLRB
- Grenningloh G etl al
Cloning and expression of the 58 kd beta subunit of the
inhibitory glycine receptor.
Neuron. 1990 Jun;4(6):963-70.
PMID: 2163264
- Barnard EA.
Receptor classes and the transmitter-gated ion channels.
Trends Biochem Sci. 1992 Oct;17(10):368-74. Review.
PMID: 1360717
Component-of
glycine receptor