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glycine receptor subunit alpha-2 (GLRA2)
Function:
- alpha subunit of glycine receptor
Structure:
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
Compartment: cell junction, synapse, postsynaptic membrane
Alternative splicing: named isoforms=2
Pathology: the alpha subunit binds strychnine
General
glycine receptor alpha (glycine receptor strychnine-binding subunit)
glycoprotein
Properties
SIZE: entity length = 452 aa
MW = 52 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-27}
exoplasmic domain {28-253}
MOTIF: N-glycosylation site {N72}
N-glycosylation site {N103}
cysteine residue {C172}
MODIFICATION: cysteine residue {C186}
cysteine residue {C186}
MODIFICATION: cysteine residue {C172}
cysteine residue {C232}
MODIFICATION: cysteine residue {C243}
cysteine residue {C243}
MODIFICATION: cysteine residue {C232}
transmembrane domain {254-280}
cytoplasmic loop {281-286}
transmembrane domain {287-304}
exoplasmic loop {305-318}
transmembrane domain {319-342}
cytoplasmic loop {343-423}
transmembrane domain {424-441}
exoplasmic domain {442-452}
Database Correlations
OMIM 305990
UniProt P23416
PFAM correlations
Entrez Gene 2742
Kegg hsa:2742
References
- Grenningloh G, Pribilla I, Prior P, Multhaup G,
Beyreuther K, Taleb O, Betz H.
Cloning and expression of the 58 kd beta subunit of the
inhibitory glycine receptor.
Neuron. 1990 Jun;4(6):963-70.
PMID: 2163264 [PubMed - indexed for MEDLINE]
- Grenningloh G, Schmieden V, Schofield PR, Seeburg PH,
Siddique T, Mohandas TK, Becker CM, Betz H.
Alpha subunit variants of the human glycine receptor:
primary structures, functional expression and chromosomal
localization of the corresponding genes.
EMBO J. 1990 Mar;9(3):771-6.
PMID: 2155780
- UniProt :accession P23416