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glycine receptor alpha (glycine receptor strychnine-binding subunit)
Pathology:
- alpha subunit binds strychnine [4]
Specific
glycine receptor alpha-3
glycine receptor subunit alpha-1; glycine receptor 48 kD subunit; glycine receptor strychnine-binding subunit (GLRA1)
glycine receptor subunit alpha-2 (GLRA2)
General
oligomerizing protein
phosphoprotein
protein subunit
transmembrane 4e protein
Properties
SIZE: MW = 48 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
cysteine residue {N_TERMINAL}
MODIFICATION: cysteine residue {N_TERMINAL}
ligand-binding site
transmembrane domain {TM1}
cytoplasmic loop {Cl2}
transmembrane domain {TM2}
exoplasmic loop
transmembrane domain {TM3}
cytoplasmic loop {Cl2}
MOTIF: Ser phosphorylation site {S391}
transmembrane domain {TM4}
exoplasmic domain {C-TERMINAL}
References
- Grenningloh G, Pribilla I, Prior P, Multhaup G,
Beyreuther K, Taleb O, Betz H.
Cloning and expression of the 58 kd beta subunit of the
inhibitory glycine receptor.
Neuron. 1990 Jun;4(6):963-70.
PMID: 2163264 [PubMed - indexed for MEDLINE]
- Grenningloh G, Schmieden V, Schofield PR, Seeburg PH,
Siddique T, Mohandas TK, Becker CM, Betz H.
Alpha subunit variants of the human glycine receptor:
primary structures, functional expression and chromosomal
localization of the corresponding genes.
EMBO J. 1990 Mar;9(3):771-6.
PMID: 2155780
- Sontheimer et al Neuron 1989 May;2(5):1491-7
- Barnard EA.
Receptor classes and the transmitter-gated ion channels.
Trends Biochem Sci. 1992 Oct;17(10):368-74. Review.
PMID: 1360717
- UniProt :accession O75311
Component-of
glycine receptor