Contents

Search

glycine receptor

Function: 1) neurotransmitter-gated ion channel 2) binding of glycine to its receptor increases the chloride conductance, thus produces hyperpolarization (inhibition of neuronal firing) 3) associates with 93 kD cytoplasmic protein Structure: - pentamer composed of alpha & beta subunits Compartment: membrane Alternative splicing: named isoforms=2 Expression: widely distributed throughout central nervous system Pathology: - alpha subunit binds strychnine

Interactions

molecular events

Related

glycine

General

cell surface receptor Cl- channel multisubunit protein

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site allosteric site ION-PERMEABILITY: Cl- HCO3- SUBUNITS: glycine receptor alpha MOTIF: exoplasmic domain {N-TERMINAL} MOTIF: cysteine residue {N_TERMINAL} MODIFICATION: cysteine residue {N_TERMINAL} cysteine residue {N_TERMINAL} MODIFICATION: cysteine residue {N_TERMINAL} ligand-binding site transmembrane domain {TM1} cytoplasmic loop {Cl2} transmembrane domain {TM2} exoplasmic loop transmembrane domain {TM3} cytoplasmic loop {Cl2} MOTIF: Ser phosphorylation site {S391} transmembrane domain {TM4} exoplasmic domain {C-TERMINAL} glycine receptor subunit beta MOTIF: exoplasmic domain {1-265} MOTIF: signal sequence {1-22} N-glycosylation site {N54} cysteine residue {C183} MODIFICATION: cysteine residue {C197} cysteine residue {C197} MODIFICATION: cysteine residue {C183} N-glycosylation site {N242} transmembrane domain {266-290} cytoplasmic loop {291-298} transmembrane domain {299-316} exoplasmic loop {317-330} transmembrane domain {331-354} cytoplasmic loop {355-478} transmembrane domain {479-496} exoplasmic domain {497-497} MISC-INFO: INHIBITOR = STRYCHNINE

References

  1. Grenningloh G, Pribilla I, Prior P, Multhaup G, Beyreuther K, Taleb O, Betz H. Cloning and expression of the 58 kd beta subunit of the inhibitory glycine receptor. Neuron. 1990 Jun;4(6):963-70. PMID: 2163264 [PubMed - indexed for MEDLINE]
  2. Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 1990 Mar;9(3):771-6. PMID: 2155780
  3. Barnard EA. Receptor classes and the transmitter-gated ion channels. Trends Biochem Sci. 1992 Oct;17(10):368-74. Review. PMID: 1360717

Components

glycine receptor alpha (glycine receptor strychnine-binding subunit) glycine receptor subunit beta; glycine receptor 58 kD subunit (GLRB)