Search
glycerophosphodiester phosphodiesterase 1 (membrane interacting protein of RGS16, RGS16-interacting membrane protein, GDE1, MIR16)
Function:
1) glycerophosphoinositol phosphodiesterase activity
2) little or no activity towards glycerophosphocholine
3) GDE1 activity can be modulated by G-protein signaling pathways
4) interacts with RGS16
5) interacts with PRAF2
1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O
myo-inositol + sn-glycerol 3-phosphate
Structure:
1) N-glycosylated
2) belongs to the glycerophosphoryl diester phosphodiesterase family
3) contains 1 GDPD domain
Compartment:
- cytoplasm, membrane
- perinuclear vesicles & cell membrane
Alternative splicing: named isoforms=2
Expression: widely expressed
General
glycoprotein
phosphodiesterase
transmembrane 2 protein
Properties
SIZE: MW = 38 kD
entity length = 331 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: cytoplasmic domain {1-3}
transmembrane domain {4-24}
exoplasmic loop {25-247}
MOTIF: N-glycosylation site {N168}
N-glycosylation site {N198}
transmembrane domain {248-268}
cytoplasmic domain {269-331}
Database Correlations
OMIM 605943
UniProt Q9NZC3
Pfam PF03009
ENZYME 3.1.4.44
References
UniProt :accession Q9NZC3