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glycerol kinase (glycerokinase, GK, ATP:glycerol 3-phosphotransferase)
Function:
- key enzyme in the regulation of glycerol uptake & metabolism
- glycerol utilization, rate-limiting step
ATP + glycerol ADP + sn-glycerol 3-phosphate
Structure: belongs to the FGGY kinase family
Compartment:
- mitochondrial outer membrane
- peripheral membrane, cytoplasmic side
- cytoplasm
- in sperm & fetal tissues, majority of the enzyme is bound to mitochondria, but in adult tissues, including liver, it is found in cytoplasm
Alternative splicing: named isoforms=3
Expression:
- highly expressed in the liver, kidney & testis
- isoforms 2 & 3 are expressed specifically in testis & fetal liver, but not in the adult liver
Pathology:
- defects in GK are the cause of GK deficiency
Interactions
molecular events
Specific
glycerol kinase 2; GK 2; glycerokinase 2; ATP:glycerol 3-phosphotransferase 2; glycerol kinase, testis specific 2 (GK2, GKP2, GKTA)
glycerol kinase 3; GK 3; glycerokinase 3; ATP:glycerol 3-phosphotransferase 3; glycerol kinase, testis specific 1 (GK3P, GKP3, GKTB)
glycerol kinase 5 (ATP:glycerol 3-phosphotransferase, GK5)
General
kinase or ATP-phosphotransferase
Properties
MOTIF: kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Database Correlations
OMIM correlations
UniProt P32189
ENZYME 2.7.1.30
References
- UniProt :accession P32189
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GK