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glycerate kinase (HBeAg-binding protein 4, GLYCTK, HBEBP4, LP5910)
Function:
- converts glycerate to 3-phosphoglycerate ATP + (R)-glycerate ADP + 3-phospho-(R)-glycerate
Structure: belongs to the glycerate kinase type-2 family
Compartment:
- isoform 1: cytoplasm
- isoform 2: cytoplasm, mitochondrion
Alternative splicing: named isoforms=7
Expression: widely expressed
Pathology:
- defects in GLYCTK are the cause of D-glyceric acidemia
General
kinase or ATP-phosphotransferase
Properties
SIZE: MW = 55 kD
entity length = 523 aa
COMPARTMENT: mitochondria
cytoplasm
MOTIF: alanine-rich region {94-97}
MOTIF: alanine residue (SEVERAL)
Database Correlations
OMIM 220120
UniProt Q8IVS8
Pfam PF05161
ENZYME 2.7.1.31
References
UniProt :accession Q8IVS8