solute carrier family 2 member 6; glucose transporter type 6; GLUT-6; glucose transporter type 9; GLUT-9 (SLC2A6, GLUT6)

Function: - facilitative glucose transporter - binds cytochalasin B with low affinity Structure: - belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily Compartment: - cell membrane - the dileucine internalization motif is critical for intracellular sequestration (putative) Expression: - highly expressed in brain, spleen & peripheral blood leukocytes Note: - has been described as GLUT9 in literature, but this name has already been used for SLC2A9

General

glucose transporter glycoprotein solute carrier family 2 (SLC2, SLC2A)

Properties

SIZE: entity length = 507 aa MW = 55 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-37} MOTIF: Dileucine internalization motif {5-6} Ser phosphorylation site {S23} transmembrane domain {38-58} exoplasmic loop {59-81} transmembrane domain {82-102} cytoplasmic loop {103-111} transmembrane domain {112-132} exoplasmic loop {133-140} transmembrane domain {141-161} cytoplasmic loop {162-168} transmembrane domain {169-189} exoplasmic loop {190-194} transmembrane domain {195-215} cytoplasmic loop {216-289} transmembrane domain {290-310} exoplasmic loop {311-314} transmembrane domain {315-335} cytoplasmic loop {336-339} transmembrane domain {340-360} exoplasmic loop {361-395} MOTIF: N-glycosylation site {N370} transmembrane domain {396-416} cytoplasmic loop {417-435} transmembrane domain {436-456} exoplasmic loop {457-462} transmembrane domain {463-483} cytoplasmic domain {484-507}

Database Correlations

OMIM 606813 UniProt Q9UGQ3 Pfam PF00083 Kegg hsa:1118