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glutathione S-transferase theta-1 (GST class-theta-1, glutathione transferase T1-1, GSTT1)
Function:
- conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
- acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride & 4-nitrophenethyl bromide
- displays glutathione peroxidase activity with cumene hydroperoxide
RX + glutathione HX + R-S-glutathione
Structure:
- homodimer
- belongs to the GST superfamily. Theta family
Compartment: cytoplasm
Expression:
- found in erythrocyte
- expressed at low levels in liver
- in lung, expressed at low levels in Clara cells & ciliated cells at the alveolar/bronchiolar junction, absent from epithelial cells of larger bronchioles
Polymorphism:
- the GSTT1 gene is absent from 38% of the population
- the presence or absence of the GSTT1 gene is coincident with the conjugator (GSST1+) & non-conjugator (GSTT1-) phenotypes respectively
- the GSTT1+ phenotype can catalyze the glutathione conjugation of dichloromethane
Laboratory:
- glutathione S-transferase T1 Ab in serum
General
glutathione transferase
Properties
SIZE: entity length = 240 aa
MW = 27 kD
COMPARTMENT: cytoplasm
MOTIF: serine residue {S11}
Database Correlations
OMIM 600436
UniProt P30711
PFAM correlations
KEGG correlations
ENZYME 2.5.1.18
References
- UniProt :accession P30711
- SHMPD, The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=GSTT1