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glutaminyl-peptide cyclotransferase (QC, glutaminyl-tRNA cyclotransferase, glutaminyl cyclase, QPCT)
Function:
1) biosynthesis of pyroglutamyl peptides
2) has bias against acidic & tryptophan residues adjacent to N-terminal glutaminyl residue
3) indifferent to chain length after the 2nd residue
L-glutaminyl-peptide 5-oxoprolyl-peptide + NH3
General
acyltransferase
glycoprotein
Properties
SIZE: MW = 41 kD
entity length = 361 aa
MOTIF: signal sequence {1-28}
N-glycosylation site {N49}
N-glycosylation site {N296}
Database Correlations
OMIM 607065
UniProt Q16769
Pfam PF04389
ENZYME 2.3.2.5
References
UniProt :accession Q16769