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glutamine synthetase; glutamate ammonia ligase (GLUL, GLNS)
Function:
ATP + L-glutamate + NH3 ADP + phosphate + L-glutamine
Structure:
- homooctamer
- belongs to the glutamine synthetase family
Compartment: cytoplasm
Expression:
- within the rat CNS, preferentially expressed in astrocytes
Pathology:
- defects in GLUL are the cause of congenital systemic glutamine deficiency
General
ligase or synthetase
phosphoprotein
Properties
SIZE: entity length = 373 aa
MW = 42 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y104}
Tyr phosphorylation site {Y180}
Database Correlations
OMIM 138290
UniProt P15104
PFAM correlations
Kegg hsa:2752
ENZYME 6.3.1.2
References
- UniProt :accession P15104
- Thug I, Gouw A, Dizon P, Zhao L, Zhang H, Zawaideh R,
Solovyeva A, Timiras PS
Long-term effects of growth factors on neuroglia: proliferation,
dedifferentiation and neurogenesis
Aging: Mechanisms and Prevention
34th Annual Meeting of the American Aging Association
June 3-6, 2005, Oakland CA
- Wikipedia; Note: glutamine synthetase entry
http://en.wikipedia.org/wiki/glutamine_synthetase