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excitatory amino acid transporter 5; retinal glutamate transporter; solute carrier family 1 member 7 (SLC1A7 EAAT5)
Function:
- transports L-glutamate
- L-glutamate uptake is Na+ & voltage-dependent & chloride-independent
- associated chloride conductance may participate in visual processing
- interacts with the PDZ domains of DLG4
Structure:
- belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family
Compartment: membrane
Expression:
- expressed primarily in retina
- detectable in liver, heart, muscle & brain
General
glutamate/aspartate transporter (excitatory amino acid transporter)
glycoprotein
solute carrier family 1 (SLC1 SLC1A)
transmembrane 10 protein
Properties
SIZE: entity length = 560 aa
MW = 61 kD
COMPARTMENT: plasma membrane
CELL: neuroglia
MOTIF: cytoplasmic domain {1-16}
transmembrane domain {17-37}
exoplasmic loop {38-59}
transmembrane domain {60-80}
cytoplasmic loop {81-93}
transmembrane domain {94-114}
exoplasmic loop {115-216}
MOTIF: N-glycosylation site {N191}
transmembrane domain {217-237}
cytoplasmic loop {238-259}
transmembrane domain {260-280}
exoplasmic loop {281-299}
transmembrane domain {300-320}
cytoplasmic loop {321-329}
transmembrane domain {330-350}
exoplasmic loop {351-371}
transmembrane domain {372-392}
cytoplasmic loop {393-413}
transmembrane domain {414-434}
exoplasmic loop {435-456}
transmembrane domain {457-477}
cytoplasmic domain {478-560}
ION-PERMEABILITY: Na+
K+
Database Correlations
OMIM 604471
UniProt O00341
Pfam PF00375
Entrez Gene 6512
References
UniProt :accession O00341