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excitatory amino acid transporter 3; Na+ dependent glutamate/aspartate transporter 3; excitatory amino-acid carrier 1; neuronal & epithelial glutamate transporter; solute carrier family 1 member 1 (SLC1A1, EAAC1, EAAT3)
Function:
- transports L-glutamate & also L- & D-aspartate
- essential for terminating postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
- acts as a symporter by cotransporting Na+
- negatively regulated by ARL6IP5 (putative)
- neuronal glutamate/aspartate transporter
- interacts with ARL6IP5/PRAF3 (putative)
Structure:
- glycosylated
- belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family
Compartment: membrane
Expression:
- expressed in all tissues tested including:
- liver, muscle, testis, ovary, retinoblastoma cell line, neurons & brain
- dense expression in substantia nigra, red nucleus, hippocampus & in cerebral cortical layers)
Pathology:
- defects in SLC1A1 may be a cause of
- dicarboxylicamino aciduria
General
glutamate/aspartate transporter (excitatory amino acid transporter)
glycoprotein
solute carrier family 1 (SLC1 SLC1A)
transmembrane 10 protein
Properties
SIZE: entity length = 524 aa
MW = 57 kD
COMPARTMENT: plasma membrane
CELL: neuroglia
MOTIF: cytoplasmic domain {1-18}
transmembrane domain {19-38}
exoplasmic loop {39-61}
MOTIF: N-glycosylation site {N43}
transmembrane domain {62-82}
cytoplasmic loop {83-93}
transmembrane domain {94-114}
exoplasmic loop {115-209}
MOTIF: N-glycosylation site {N178}
N-glycosylation site {N195}
transmembrane domain {210-229}
cytoplasmic loop {230-253}
transmembrane domain {254-273}
exoplasmic loop {274-289}
transmembrane domain {290-309}
cytoplasmic loop {310-315}
transmembrane domain {316-335}
exoplasmic loop {336-361}
transmembrane domain {362-381}
cytoplasmic loop {382-391}
transmembrane domain {392-411}
exoplasmic loop {412-419}
transmembrane domain {420-439}
cytoplasmic domain {440-524}
ION-PERMEABILITY: Na+
K+
Database Correlations
OMIM correlations
UniProt P43005
Pfam PF00375
Entrez Gene 6505
Kegg hsa:6505
References
- UniProt :accession P43005
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC1A1