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glutamate receptor zeta-1; N-methyl-D-aspartate receptor subunit NR1 (GRIN1 NMDAR1)
Function:
- NMDA receptor subunit
- high Ca+2 permeability
- voltage-dependent sensitivity to Mg+2
- mediated by glycine
- plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition & learning
- mediates neuronal functions in glutamate neurotransmission
- involved in the cell surface targeting of NMDA receptors (putative)
- forms heteromeric channel of:
a) zeta subunit (GRIN1)
b) epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
c) 3rd subunit (GRIN3A or GRIN3B)
- disulfide-linked
- found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B & PPP2CB
- interacts with DLG4 & MPDZ (putative)
- NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC
- dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB)
- phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex & the NMDAR channel activity (putative)
Structure:
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
- disulfide-linked
Compartment:
- cell membrane
- cell junction, synapse, postsynaptic cell membrane (putative)
- postsynaptic density (putative)
- enriched in post-synaptic plasma membrane & post-synaptic densities
Alternative splicing: named isoforms=5
General
glutamate receptor zeta
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 938 aa
MW = 105 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {19-559}
MOTIF: signal sequence {1-18}
N-glycosylation site {N61}
cysteine residue {C79}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N203}
N-glycosylation site {N239}
N-glycosylation site {N276}
N-glycosylation site {N300}
N-glycosylation site {N350}
N-glycosylation site {N368}
N-glycosylation site {N440}
N-glycosylation site {N471}
N-glycosylation site {N491}
Glycine binding {516-518}
binding site
SITE: 523-523
FOR-BINDING-OF: Glycine
transmembrane domain {560-580}
cytoplasmic loop {581-636}
transmembrane domain {637-657}
exoplasmic loop {658-812}
MOTIF: binding site
SITE: 688-688
FOR-BINDING-OF: Glycine
binding site
SITE: 732-732
FOR-BINDING-OF: Glycine
transmembrane domain {813-833}
cytoplasmic domain {834-938}
MOTIF: Ser phosphorylation site {S889}
Ser phosphorylation site {S890}
Ser phosphorylation site {S896}
Ser phosphorylation site {S897}
Database Correlations
OMIM 138249
UniProt Q05586
PFAM correlations
Entrez Gene 2902
Kegg hsa:2902
References
- Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E,
Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al.
Molecular diversity of the NMDA receptor channel.
Nature. 1992 Jul 2;358(6381):36-41.
PMID: 1377365
- Hynd MR, Scott HL, Dodd PR.
Selective loss of NMDA receptor NR1 subunit isoforms in
Alzheimer's disease.
J Neurochem. 2004 Apr;89(1):240-7.
PMID: 15030408
- UniProt :accession Q05586
- Wikipedia; Note: NMDA receptor entry
http://en.wikipedia.org/wiki/NMDA_receptor