glutamate receptor, ionotropic kainate 5; glutamate receptor KA-2; KA2; excitatory amino acid receptor 2; EAA2 (GRIK5)

Function: - postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system - receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD - associates with GRIK1 (both edited & unedited versions), GRIK2, or GRIK3 to form functional channels - homomeric associations do not produce any channel activity (putative) Structure: - belongs to the glutamate-gated ion channel (TC 1.A.10) family Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane

General

glycoprotein membrane protein receptor

Properties

SIZE: entity length = 980 aa MW = 109 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-544} MOTIF: signal sequence {1-14} N-glycosylation site {N219} N-glycosylation site {N271} N-glycosylation site {N285} N-glycosylation site {N322} N-glycosylation site {N372} N-glycosylation site {N394} N-glycosylation site {N400} N-glycosylation site {N407} N-glycosylation site {N414} N-glycosylation site {N478} transmembrane domain {545-565} cytoplasmic loop {566-622} transmembrane domain {623-643} exoplasmic loop {644-803} transmembrane domain {804-824} cytoplasmic domain {825-980} MOTIF: arginine-rich region {860-866} MOTIF: arginine residue (SEVERAL)

Database Correlations

OMIM 600283 UniProt Q16478 PFAM correlations Entrez Gene 2901 Kegg hsa:2901

References

UniProt :accession Q16478