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glutamate receptor, ionotropic kainate 4; glutamate receptor KA-1; KA1; excitatory amino acid receptor 1; EAA1 (GRIK4 GRIK)
Function:
- postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system
- forms a heteromeric channel with GRIK1 or GRIK3
Structure:
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
Compartment:
- cell membrane
- cell junction, synapse, postsynaptic cell membrane
General
glutamate receptor gamma
glycoprotein
Properties
SIZE: entity length = 956 aa
MW = 107 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-545}
MOTIF: signal sequence {1-20}
N-glycosylation site {N158}
N-glycosylation site {N220}
N-glycosylation site {N272}
N-glycosylation site {N286}
N-glycosylation site {N323}
N-glycosylation site {N408}
N-glycosylation site {N415}
N-glycosylation site {N479}
transmembrane domain {546-566}
cytoplasmic loop {567-623}
transmembrane domain {624-644}
exoplasmic loop {645-804}
transmembrane domain {805-825}
cytoplasmic domain {826-956}
MOTIF: arginine-rich region {862-865}
MOTIF: arginine residue (SEVERAL)
Database Correlations
OMIM 600282
UniProt Q16099
PFAM correlations
Entrez Gene 2900
Kegg hsa:2900
References
UniProt :accession Q16099