glutamate receptor-interacting protein 2; GRIP-2 (GRIP2 KIAA1719)

Function: - may play a role as a localized scaffold for the assembly of a multiprotein signaling complex & as mediator of the trafficking of its binding partners at specific subcellular location in neurons (putative) - interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 & GRIPAP1 - can form homomultimers & heteromultimers with GRIP1 - interacts with the C-terminal tail of PRLHR Structure: - PDZ 5 mediates the C-terminal binding of GRIA2 & GRIA3 - PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 - PDZ 7 mediates interaction with CSPG4 (putative) - belongs to the GRIP2 family - contains 7 PDZ domain (DHR domain)s Compartment: - cytoplasm (putative) - membrane, peripheral membrane (putative) Alternative splicing: - named isoforms=3 - intron retention

General

glutamate receptor-interacting protein (GRIP) oligomerizing protein

Properties

SIZE: entity length = 1043 aa MW = 113 kD COMPARTMENT: cytoplasm MOTIF: PDZ domain NAME: PDZ domain SITE: 48-131 PDZ domain NAME: PDZ domain SITE: 148-234 PDZ domain NAME: PDZ domain SITE: 248-332 PDZ domain NAME: PDZ domain SITE: 456-545 membrane region PDZ domain NAME: PDZ domain SITE: 557-641 PDZ domain NAME: PDZ domain SITE: 656-738 PDZ domain NAME: PDZ domain SITE: 941-1023

Database Correlations

UniProt Q9C0E4 Pfam PF00595

References

UniProt :accession Q9C0E4