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glutamate receptor-interacting protein 1; GRIP-1 (GRIP1)
Function:
1) localized scaffold for the assembly of a multiprotein signaling complex
2) mediator of trafficking of its binding partners in neurons
3) interacts with EPHA7, EPHB2, KIF5A, KIF5B, KIF5C, GRIA2, GRIA3, GRASP1, PPFIA1, PPFIA4, FRAS1, PTPRF, EFNB1, EFNB3, liprin-alpha(s)
4) may form homomultimers or heteromultimers with GRIP2
5) forms ternary complex with GRIA2 and CSPG4
6) binds to the C-terminus of ephrin B1 through a PDZ domain
7) GRIP1 also binds to the SVKI motif in the C-terminal region of the GluR1 & GluR2 subunits of the AMPA receptor
Structure:
- PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1 & EPHB2 & with the C-terminus of PPFIA1 & PPFIA4 PDZ 4 & PDZ 5 mediate interaction with the C-terminus of GRIA2 & GRIA3
- PDZ 4, PDZ 5 & PDZ 6 mediate homomultimers
- PDZ 7 mediates interaction with PDZ domain of GRASP1
- PDZ 7 domain binds CSPG4
- PDZ 6 mediates interaction with the C-terminus of liprins-alpha
- PDZ 1, PDZ 2 & PDZ 3 mediate interaction with the PDZ-binding motif of FRAS1 (putative)
- PDZ 4 & PDZ 5 mediate interaction with PRLHR
- contains 7 PDZ domain (DHR domain)s
Compartment:
- cytoplasmic & membrane-associated with vesicles
- peri-Golgi complexes, endoplasmic reticulum
- enriched in post-synaptic membrane & post-synaptic densities
Alternative splicing: named isoforms=2
Interactions
molecular events
General
glutamate receptor-interacting protein (GRIP)
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 1128 aa
MW = 122 kD
COMPARTMENT: cytoplasm
golgi
endoplasmic reticulum
MOTIF: Ser phosphorylation site {S43}
PDZ domain
NAME: PDZ domain
SITE: 53-136
PDZ domain
NAME: PDZ domain
SITE: 150-238
PDZ domain
NAME: PDZ domain
SITE: 252-336
PDZ domain
NAME: PDZ domain
SITE: 472-561
PDZ domain
NAME: PDZ domain
SITE: 573-658
PDZ domain
NAME: PDZ domain
SITE: 673-755
Thr phosphorylation site {T972}
PDZ domain
NAME: PDZ domain
SITE: 1004-1086
Database Correlations
OMIM 604597
UniProt Q9Y3R0
Pfam PF00595
References
- OMIM :accession 604597
- Sheng M.
Molecular organization of the postsynaptic specialization.
Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7058-61. Review.
PMID: 11416187
- UniProt :accession Q9Y3R0
Component-of
molecular complex