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glutamate receptor epsilon-4; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NR2D; EB11 (GRIN2D, NMDAR2D)

Function: - NMDA receptor subunit - high Ca+2 permeability - voltage-dependent sensitivity to Mg+2 - mediated by glycine - interacts with PDZ domains of INADL & DLG4 - forms heteromeric channel of a) zeta subunit (GRIN1) b) epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) c) 3rd subunit (GRIN3A or GRIN3B) Structure: - belongs to the glutamate-gated ion channel (TC 1.A.10) family Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane

General

glutamate receptor epsilon or glutamate receptor, ionotropic NMDA 2 (GRIN2) glycoprotein phosphoprotein

Properties

SIZE: entity length = 1336 aa MW = 144 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {28-583} MOTIF: signal sequence {1-27} N-glycosylation site {N92} glycine-rich region {281-286} N-glycosylation site {N352} N-glycosylation site {N366} N-glycosylation site {N467} N-glycosylation site {N569} transmembrane domain {584-604} cytoplasmic loop {605-656} MOTIF: asparagine residue {642} transmembrane domain {657-677} exoplasmic loop {678-844} transmembrane domain {845-865} cytoplasmic domain {866-1336} MOTIF: proline-rich region SITE: 908-916 MOTIF: proline residue (SEVERAL) alanine-rich region {1035-1040} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 1209-1213 MOTIF: proline residue (SEVERAL) alanine-rich region {1244-1247} MOTIF: alanine residue (SEVERAL) Ser phosphorylation site {S1326} PDZ recognition motif NAME: PDZ recognition motif SITE: 1334-1336 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 602717 UniProt O15399 PFAM correlations Entrez Gene 2906 Kegg hsa:2906

References

  1. UniProt :accession O15399
  2. Liu Y, Zhang J. Recent development in NMDA receptors. Chin Med J (Engl). 2000 Oct;113(10):948-56. Review. PMID: 11775847