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glutamate receptor epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C (GRIN2C NMDAR2C)
Function:
- NMDA receptor subunit
- confers relative resistance to Mg+2 block
- high Ca+2 permeability
- voltage-dependent sensitivity to Mg+2
- mediated by glycine
- interacts with PDZ domains of INADL & DLG4
- forms heteromeric channel of:
a) zeta subunit (GRIN1)
b) epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D)
c) 3rd subunit (GRIN3A or GRIN3B)
Structure:
- belongs to the glutamate-gated ion channel (TC 1.A.10) family
Compartment:
- cell membrane
- cell junction, synapse, postsynaptic cell membrane
Expression:
- mainly in brain
- predominant expression is in the cerebellum
- also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei & thalamus
- detected in the heart, skeletal muscle & pancreas
General
glutamate receptor epsilon or glutamate receptor, ionotropic NMDA 2 (GRIN2)
glycoprotein
Properties
SIZE: entity length = 1233 aa
MW = 134 kD
COMPARTMENT: plasma membrane
MOTIF: exoplasmic domain {1-553}
MOTIF: signal sequence {1-19}
N-glycosylation site {N70}
N-glycosylation site {N337}
N-glycosylation site {N438}
N-glycosylation site {N539}
transmembrane domain {554-574}
cytoplasmic loop {575-626}
MOTIF: asparagine residue {612}
transmembrane domain {627-647}
exoplasmic loop {648-814}
transmembrane domain {815-835}
cytoplasmic domain {836-1233}
MOTIF: PDZ recognition motif
NAME: PDZ recognition motif
SITE: 1231-1233
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 138254
UniProt Q14957
PFAM correlations
Entrez Gene 2905
Kegg hsa:2905
References
- UniProt :accession Q14957
- Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E,
Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al.
Molecular diversity of the NMDA receptor channel.
Nature. 1992 Jul 2;358(6381):36-41.
PMID: 1377365