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glutamate receptor epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; hNR2A; NR2A (GRIN2A, NMDAR2A)

Function: - NMDA receptor subunit - high Ca+2 permeability - voltage-dependent sensitivity to Mg+2 - activation requires binding of agonist to both types of subunits - forms heteromeric channel of a) zeta subunit (GRIN1) b) epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) c) 3rd subunit (GRIN3A or GRIN3B) - found in a complex with GRIN1 & GRIN3B - found in a complex with GRIN1, GRIN3A & PPP2CB - interacts with PDZ domains of AIP1, INADL & DLG4 - presumptive phosphorylation by PKC Structure: - belongs to the glutamate-gated ion channel (TC 1.A.10) family Compartment: - cell membrane - cell junction, synapse, postsynaptic cell membrane Expression: mRNA widely distributed.

General

glutamate receptor epsilon or glutamate receptor, ionotropic NMDA 2 (GRIN2) glycoprotein phosphoprotein

Properties

SIZE: entity length = 1464 aa MW = 165 kD COMPARTMENT: plasma membrane MOTIF: exoplasmic domain {1-555} MOTIF: signal sequence {1-22} N-glycosylation site {N75} N-glycosylation site {N340} N-glycosylation site {N380} N-glycosylation site {N443} N-glycosylation site {N444} Glutamate binding {511-513} binding site SITE: 518-518 FOR-BINDING-OF: Glutamate N-glycosylation site {N541} transmembrane domain {556-576} cytoplasmic loop {577-633} MOTIF: asparagine residue {614} transmembrane domain {634-654} exoplasmic loop {655-816} MOTIF: Glutamate binding {689-690} binding site SITE: 731-731 FOR-BINDING-OF: Glutamate; via amide nitrogen transmembrane domain {817-837} cytoplasmic domain {838-1464} MOTIF: Thr phosphorylation site {T888} Ser phosphorylation site {S912} Ser phosphorylation site {S917} Ser phosphorylation site {S929} Tyr phosphorylation site {Y943} Ser phosphorylation site {S1025} Ser phosphorylation site {S1337} Ser phosphorylation site {S1459} PDZ recognition motif NAME: PDZ recognition motif SITE: 1462-1464 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 138253 UniProt Q12879 Pfam PF00060 Entrez Gene 2903 Kegg hsa:2903

References

  1. UniProt :accession Q12879
  2. Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E, Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al. Molecular diversity of the NMDA receptor channel. Nature. 1992 Jul 2;358(6381):36-41. PMID: 1377365