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glutamate/aspartate transporter (excitatory amino acid transporter)

4 subtypes of glutamate/aspartate transporters have been defined by differences in sequence, pharmacology, tissue distribution, & channel-like properties: GLAST1 & GLAST2 are astroglial transporters GLAST3 & GLAST4 are selectively localized in neurons Function: - Glu & Aspartate transporter - transport driven by Na+/K+ exchange Expression: brain

Specific

excitatory amino acid transporter 1; Na+ dependent glutamate/aspartate transporter 1; GLAST-1; solute carrier family 1 member 3 (SLC1A3, EAAT1, GLAST, GLAST1) excitatory amino acid transporter 2; Na+ dependent glutamate/aspartate transporter 2; glutamate/aspartate transporter II; solute carrier family 1 member 2 (SLC1A2, EAAT2, GLT1) excitatory amino acid transporter 3; Na+ dependent glutamate/aspartate transporter 3; excitatory amino-acid carrier 1; neuronal & epithelial glutamate transporter; solute carrier family 1 member 1 (SLC1A1, EAAC1, EAAT3) excitatory amino acid transporter 4; Na+ dependent glutamate/aspartate transporter; solute carrier family 1 member 6 (SLC1A6, EAAT4) excitatory amino acid transporter 5; retinal glutamate transporter; solute carrier family 1 member 7 (SLC1A7 EAAT5)

General

amino acid transport protein glycoprotein phosphoprotein plasma membrane protein solute carrier family 6 (neurotransmitter transporter, SLC6, SLC6A)

Properties

SIZE: entity length = 543 aa MW = 66 kD COMPARTMENT: plasma membrane CELL: neuroglia MOTIF: cytoplasmic domain {N-TERMINAL} exoplasmic loop LOOP#: 1 exoplasmic loop LOOP#: 3 exoplasmic loop LOOP#: 4 exoplasmic loop LOOP#: 5 exoplasmic loop LOOP#: 6 glycosylation site membrane region phosphorylation site cytoplasmic domain {C-TERMINAL} ION-PERMEABILITY: Na+ K+ MISC-INFO: KM [glutamate] 2-50 UM KM [glutamate] 77 UM

References

  1. Kanai Y, Smith CP, Hediger MA. A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 1993 Dec;7(15):1450-9. Review. PMID: 7903261
  2. Pines G et al Cloning and expression of a rat brain L-glutamate transporter. Science 360:464 1992 PMID: 1448170
  3. Kanai Y, Hediger MA. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 1992 Dec 3;360(6403):467-71. PMID: 1280334