Search
glucose-6-phosphatase 2 (G6Pase 2, G-6-Pase 2, islet-specific glucose-6-phosphatase catalytic subunit-related protein, G6PC2, IGRP)
Function:
- may hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum
- may be responsible for glucose production through glycogenolysis & gluconeogenesis (putative)
- carbohydrate biosynthesis; gluconeogenesis
D-glucose 6-phosphate + H2O D-glucose + phosphate
Kinetic parameters:
- KM=0.45 mM for glucose-6-phosphate (at pH 6.5)
Structure:
- N-glycosylated
- non-glycosylated form is more unstable & is degraded through the proteasome
- belongs to the glucose-6-phosphatase family
Compartment: endoplasmic reticulum membrane
Alternative splicing: named isoforms=2
Expression:
- specifically expressed in pancreas
- detected to a lower extent in testis
- expressed by most islet cells in the pancreas (at protein level)
General
glucosidase
glycoprotein
transmembrane 9 protein
Properties
SIZE: entity length = 355 aa
MW = 41 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: exoplasmic domain {1-24}
transmembrane domain {25-45}
cytoplasmic loop {46-56}
transmembrane domain {57-77}
exoplasmic loop {78-115}
MOTIF: binding site
SITE: 79-79
FOR-BINDING-OF: Substrate
N-glycosylation site {N92}
histidine residue {H115}
transmembrane domain {116-136}
cytoplasmic loop {137-146}
transmembrane domain {147-167}
exoplasmic loop {168-168}
MOTIF: binding site
SITE: 168-168
FOR-BINDING-OF: Substrate
transmembrane domain {169-189}
MOTIF: histidine residue {H174}
cytoplasmic loop {190-211}
transmembrane domain {212-232}
exoplasmic loop {233-261}
transmembrane domain {262-282}
cytoplasmic loop {283-293}
transmembrane domain {294-314}
exoplasmic loop {315-318}
transmembrane domain {319-339}
cytoplasmic domain {340-355}
MOTIF: Prevents secretion from ER {352-355}
Database Correlations
OMIM 608058
UniProt Q9NQR9
Pfam PF01569
Kegg hsa:5781
ENZYME 3.1.3.9
References
UniProt :accession Q9NQR9