Search
glucose-6-phosphatase (G6Pase, G-6-Pase, G6PC, G6PT)
Function:
- may act both as a hydrolase & a translocase
- key enzyme in homeostatic regulation of blood glucose levels
- gluconeogenesis & glycogenolysis; last step
D-glucose 6-phosphate + H2O D-glucose + phosphate
Compartment: endoplasmic reticulum membrane
Pathology:
- defects in G6PC are the cause of glycogen storage disease type 1A
Interactions
molecular events
Related
gluconeogenesis
glycogen storage disease type-I (von Gierke type glycogen storage disease)
General
gluconeogenic enzyme
glycoprotein
membrane protein
phosphomonoesterase
Properties
SIZE: entity length = 357 aa
MW = 41 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {30-46}
transmembrane domain {59-75}
N-glycosylation site {N96}
transmembrane domain {153-169}
transmembrane domain {211-227}
transmembrane domain {296-312}
transmembrane domain {320-336}
Prevents secretion from ER {354-357}
Database Correlations
OMIM 232200
UniProt P35575
Pfam PF01569
KEGG correlations
ENZYME 3.1.3.9
References
- UniProt :accession P35575
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=G6PC