Search
glucosamine-6-phosphate isomerase 1; glucosamine-6-phosphate deaminase 1; GNPDA 1; GlcN6P deaminase 1; oscillin (GNPDA1, GNPI, HLN, KIAA0060)
Function:
- seems to trigger Ca+2 oscillations in mammalian eggs
- these oscillations serve as the essential trigger for egg activation & early development of the embryo (putative)
D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3
Structure:
- homohexamer
- belongs to the glucosamine/galactosamine-6-phosphate isomerase family
Compartment: cytoplasm (putative)
General
isomerase
Properties
SIZE: entity length = 289 aa
MW = 33 kD
COMPARTMENT: cytoplasm
MOTIF: aspartate residue {D72}
aspartate residue {D141}
histidine residue {H143}
active site
glutamate residue {E148}
Database Correlations
OMIM 601798
UniProt P46926
Pfam PF01182
Entrez Gene 10007
Kegg hsa:10007
ENZYME 3.5.99.6
References
UniProt :accession P46926