glucokinase, hexokinase-D or hexokinase-4

Function: - participates in glucose transport into cells - phosphorylation of glucose by glucokinase after internalization drives transport of glucose by making the resultant glucose-6-phosphate irreversibly trapped inside the cell Expression: - expressed only in liver & pancreatic islets Pathology: - mutations in the gene for glucokinase are involved in 60% of cases of mature onset diabetes of the young (MODY).

Specific

glucokinase, hexokinase-D or hexokinase-4 liver glucokinase pancreatic glucokinase

General

glycolytic enzyme hexokinase

Properties

SIZE: MW = 50 kD COMPARTMENT: cytoplasm CELL: hepatocyte beta cell WITHIN: islets of Langerhans MOTIF: active site

Database Correlations

OMIM correlations MORBIDMAP 138079 KEGG correlations

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998