glucocorticoid modulatory element-binding protein 2; GMEB-2; DNA-binding protein p79PIF; parvovirus initiation factor p79; PIF p79 (GMEB2, KIAA1269)

Function: - binds to glucocorticoid modulatory element present in the tyrosine aminotransferase promoter - increases sensitivity to low concentrations of glucocorticoids - interacts with glucocorticoid receptor (NR3C1) - may interact with CREB-binding protein - binds also to the transferrin receptor promoter - homodimer, & heterodimer of GMEB1 & GMEB2 Structure: contains 1 SAND domain Compartment: nucleus, cytoplasm Expression: - expressed in peripheral blood lymphocytes & fetal liver - expressed preferentially in reproductive &/or developmentally important cells, such as testis, placenta, bone marrow & fetal tissues Pathology: - essential auxiliary factor for the replication of parvoviruses - GMEB1 & GMEB2 form the parvovirus initiator complex

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 530 aa MW = 56 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: alanine-rich region {57-64} MOTIF: alanine residue (SEVERAL) SAND {81-163} MOTIF: Zn+2-binding site SITE: 110-110 DNA-binding motif SITE: 136-136 DNA-binding motif SITE: 140-140 DNA-binding motif SITE: 143-143 DNA-binding motif SITE: 154-154 Zn+2-binding site SITE: 167-167 Zn+2-binding site SITE: 171-171 Zn+2-binding site SITE: 175-175 coiled coil {304-348} Ser phosphorylation site {S373}

Database Correlations

OMIM 607451 UniProt Q9UKD1 Pfam PF01342 Entrez Gene 26205 Kegg hsa:26205

References

UniProt :accession Q9UKD1