glucocorticoid modulatory element binding protein 1; GMEB-1; parvovirus initiation factor p96; PIF p96; DNA binding protein p96PIF (GMEB1)

Function: - binds to glucocorticoid modulatory element present in the tyrosine aminotransferase promoter - increases sensitivity to low concentrations of glucocorticoids - interacts with glucocorticoid receptor (NR3C1) & NCOA2/TIF2 - may interact with HSP27 & CREB-binding protein - binds also to the transferrin receptor promoter - homodimer, & heterodimer of GMEB1 & GMEB2 Structure: contains 1 SAND domain Compartment: nucleus. cytoplasm. Note: may be also cytoplasmic Alternative splicing: named isoforms=2 Pathology: - essential auxiliary factor for the replication of parvoviruses - GMEB1 & GMEB2 form the parvovirus initiator complex

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 573 aa MW = 63 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl SAND {82-166} MOTIF: Zn+2-binding site SITE: 113-113 Ser phosphorylation site {S129} DNA-binding motif SITE: 139-139 DNA-binding motif SITE: 143-143 DNA-binding motif SITE: 146-146 DNA-binding motif SITE: 157-157 Zn+2-binding site SITE: 170-170 Zn+2-binding site SITE: 174-174 Zn+2-binding site SITE: 178-178 coiled coil {321-367}

Database Correlations

OMIM 604409 UniProt Q9Y692 Pfam PF01342 Entrez Gene 10691 Kegg hsa:10691

References

UniProt :accession Q9Y692