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glucagon receptor; GL-R (GCGR)
Function:
- receptor for glucagon
- role in regulating blood glucose by controlling the rate of hepatic glucose production & insulin secretion
- activity is mediated by G proteins which activate adenylyl cyclase & also a phosphatidylinositol-Ca+2 second messenger system
- stimulates both cAMP & Ca+2 accumulation
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane; multi-pass membrane protein
Pathology:
- candidate for defects in diabetes mellitus type-2 (NIDDM)
- Ser variant in position 40 is found in some type-2 diabetics, but also in non-diabetic subjects
Related
glucagon; contains: glicentin; glicentin-related polypeptide; GRPP; oxyntomodulin; OXM; OXY; glucagon-like peptide 1; GLP-1; glucagon-like peptide 1(7-37); GLP-1(7-37); glucagon-like peptide 1(7-36); GLP-1(7-36); glucagon-like peptide 2; GLP-2 (GCG)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 477 aa
MW = 54 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
exoplasmic domain {26-142}
MOTIF: N-glycosylation site {N46}
N-glycosylation site {N59}
N-glycosylation site {N74}
N-glycosylation site {N78}
transmembrane domain {143-166}
cytoplasmic loop {167-173}
transmembrane domain {174-193}
exoplasmic loop {194-225}
transmembrane domain {226-249}
cytoplasmic loop {250-263}
transmembrane domain {264-285}
exoplasmic loop {286-303}
transmembrane domain {304-326}
cytoplasmic loop {327-350}
transmembrane domain {351-369}
exoplasmic loop {370-381}
transmembrane domain {382-404}
cytoplasmic domain {405-477}
MISC-INFO: LIGAND = GLUCACON
Database Correlations
OMIM 138033
MORBIDMAP 138033
UniProt P47871
PFAM correlations
Kegg hsa:2642
References
- UniProt :accession P47871
- Holz GG, Habener JF.
Signal transduction crosstalk in the endocrine system:
pancreatic beta-cells and the glucose competence concept.
Trends Biochem Sci. 1992 Oct;17(10):388-93. Review.
PMID: 1455507
- Jelinek LJ, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S,
Bensch PA, Kuijper JL, Sheppard PO, Sprecher CA, et al.
Expression cloning and signaling properties of the rat
glucagon receptor.
Science. 1993 Mar 12;259(5101):1614-6.
PMID: 8384375