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glucagon-like peptide 1 receptor; GLP-1 receptor; GLP-1-R; GLP-1R (GLP1R)
Function:
- receptor for glucagon-like peptide 1
- activity is mediated by G proteins which activate adenylyl cyclase
Structure: belongs to the G-protein coupled receptor 2 family
Compartment: cell membrane
Pharmacology:
- incretin mimetics (GLP1R agonists) are use in treatment of diabetes mellitus type 2
Related
glucagon-like peptide 1 (GLP-1) receptor agonist; incretin mimetic; GLP-1 mimetic; GLP-1 agonist; glutide; GLP-1RA
glucagon-like peptide 1 (GLP1)
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 463 aa
MW = 53 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
exoplasmic domain {24-145}
MOTIF: N-glycosylation site {N63}
N-glycosylation site {N82}
N-glycosylation site {N115}
transmembrane domain {146-168}
cytoplasmic loop {169-176}
transmembrane domain {177-196}
exoplasmic loop {197-227}
transmembrane domain {228-252}
cytoplasmic loop {253-264}
transmembrane domain {265-288}
exoplasmic loop {289-303}
transmembrane domain {304-329}
cytoplasmic loop {330-351}
transmembrane domain {352-372}
exoplasmic loop {373-387}
transmembrane domain {388-408}
cytoplasmic domain {409-463}
MISC-INFO: LIGAND = GLUCACON_LIKE_PEPTIDE_1
Database Correlations
OMIM 138032
UniProt P43220
PFAM correlations
Kegg hsa:2740
References
- UniProt :accession P43220
- Wikipedia; Note: glucagon-like peptide 1 entry
http://en.wikipedia.org/wiki/glucagon-like_peptide-1
- Holz GG, Habener JF.
Signal transduction crosstalk in the endocrine system:
pancreatic beta-cells and the glucose competence concept.
Trends Biochem Sci. 1992 Oct;17(10):388-93. Review.
PMID: 1455507