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globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (Forssman glycolipid synthetase-like protein, GBGT1)
Function:
1) glycosylation
2) catalyzes formation of some glycolipid via addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate
3) the glycolipids may serve for adherence of some pathogens
4) in contrast to its mouse or canine ortholog, does not mediate formation of Forssman glycolipid (Forssman antigen), which does not exist in human
Cofactor: Mn+2 Manganese
Structure:
- conserved DXD motif is involved in cofactor binding
- Mn+2 interacts with the beta-phosphate group of UDP & may have a role in catalysis
- belongs to the glycosyltransferase 6 family
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- widely expressed
- expressed in placenta, ovary, peripheral blood leukocytes > liver, thymus, testis
General
glycoprotein
glycosyltransferase
membrane protein
Properties
SIZE: MW = 40 kD
entity length = 347 aa
COMPARTMENT: cellular membrane
MOTIF: transmembrane domain {6-26}
N-glycosylation site {N108}
manganese [Mn]-binding site
SITE: 206-206
manganese [Mn]-binding site
SITE: 208-208
Database Correlations
OMIM 606074
UniProt Q8N5D6
Pfam PF03414
ENZYME 2.4.1.-
References
- UniProt :accession Q8N5D6
- GGDB; NOTE=GlycoGene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp